General Cell Lines and Cell Cultures
Eurofins Discoverx KILR HL-60 Cell Pool, Cell Pool. (97-1039P046)
The KILR HL-60 cell pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint modulators, bispecifics, CAR-T, etc.) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell pool is a heterogeneous population of HL-60 cells that overexpress a ProLabel-tagged housekeeping gene. Upon effector cells-mediated cell lysis, ProLabel is released to the media, where EA in the detection kit produces an EFC signal proportional to the level of ProLabel released. This allows for calculation of percent lysis of the KILR cell pool. This stable cell pool is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kilr.
ATCC Bacillus pacificus
Bacillus pacificus strain NRS 248 is a xylose-positive variant. This bacterium is whole-genome sequenced and is a microbiome standard component.
Eurofins Discoverx InCELL Hunter Jurkat RIPK1 Kinase Binding Cell Line, 2 vials. (96-0076C19)
The InCELL Hunter Jurkat RIPK1 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of RIPK1 via detection of RIPK1 levels. This product uses EFC technology. The cell line included overexpresses RIPK1 target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
ATCC JH4 clone 1; Lung; Guinea Pig (Cavia porcellus)
There is a Permit requirement: License form needed to be completed Material Transfer Agreement Addendum for Screening Application
The forms are available here: https://www.atcc.org/support/order-support/permits-and-restrictions
ATCC Neisseria gonorrhoeae; genomic DNA
Genomic DNA isolated from Neisseria gonorrhoeae. This bacterial strain is also available as ATCC Catalog No. 53421™.
